Exemestane belongs to the aromatase inhibitors of the 3rd generation and, like all other aromatase inhibitors, was also developed for the treatment of estrogen-related breast cancer in women.
In contrast to older aromatase inhibitors, exemestane docks firmly to the aromatase enzyme and can thus permanently deactivate it. This compound can also be dissolved again, causing the aromatase enzyme to become active again.
In bodybuilding, exemestane is used to suppress the side effects of anabolic and androgenic steroids. The steroids aromatizing by anabolic abuse are largely bound by the active substance exemestane.
Aromasin contains exemestane, a very efficient aromatase inhibitor. The activity of the aromatase enzyme is suppressed by up to 98%, which means a reduction of the estrogen level by up to 85%. By comparison, aromatase inhibitors such as anastrozole or letrozole reduce estrogen levels by almost 80%. For this reason exemestane is the most appreciated aromatase inhibitor among bodybuilders.
In this context, it should be noted that estrogen also has some anabolic effect and a strong decrease in estrogen levels through the use of aromatase inhibitors such as exemestane during the use of anabolic androgenic steroids, can result in reduced increases in muscle mass.
hot flashes, nausea, fatigue, sweating, headache, insomnia, depression, decrease in lymphocytes, thrombocytopenia, leukopenia, increase in liver enzymes, hypertrichosis, hair loss, hoarseness, acne
Application / Dosage:
In bodybuilding, half a tablet (12.5mg exemestane) is usually used daily, or one tablet (25mg exemestane) every 2 days. In the final phase of a competition preparation, some bodybuilders take 25mg exemestane daily.
It is optimal to take exemestane after a high-fat meal, as it can increase bioavailability by up to 40 percent. According to the manufacturer, it takes about a week for stable blood levels to be achieved when taking exemestane.