Similar to Somatropin, HGH Fragment 176-191 stimulates lipolysis (fat decomposition) and inhibits lipogenesis (transformation of fat-free foods into body fat) in in humans.
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HGH Fragment 176-191 is a Growth Hormone Releasing Factor (GRF) analogue that elicits growth hormone effects.
It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is added at the N-terminus. The human growth hormone peptide fragment 176-191, also known as HGH Frag 176-191, is a modified form of amino acids 176-191 of the HGH polypeptide (somatropin). Researchers from Prague University have found that the effects of HGH on fat reduction are controlling an area near the end of the growth hormone molecule. This section, which consists of amino acids 176-191, represents less than 10% of the total size of the HGH molecule and have no effect on growth or insulin resistance. It mimics the way human growth hormone regulates the metabolism of fats, but without side effects.
The in vivo effects of these segments of the synthetic peptide HGH 176-191 were investigated. Researchers suggests that HGH 176-191 induces a short-term increase in blood glucose and a steady increase in plasma insulin along with other fragments such as 172-191, 177-191 and 178-191. In addition, the research showed that the functionality of the peptide depends not only on the information sequence but also on the right physical constellation. This fragment is characterized by high protease accessibility and is rich in proline, it affects the change in the cytoplasmic domain of the erythrocyte membrane protein, serving as a hinge for rotating two subdomains. Such a residue plays a significant role in the transformational changes that are then bound to peripheral protein binding in some body cells.
In another scientific study, the 500 mcg dose of said hormone increased lipolytic activity in adipose tissues without adversely affecting blood glucose levels. It behaves like human growth hormone (HGH), it does not cause hyperglycemia and can be used to remove excess abdominal fat, a significant aspect of HIV-treatment.
Similar to Somatropin, HGH Fragment 176-191 stimulates fat decomposition and inhibits transformation of fat-free foods into body fat in humans.
HGH Fragment 176-191 is recommended to be used 1 to 3 times a day in an amount of 250-1000 mcg per single dose. It should be administered in the morning, before training and before bedtime.
The peptide may also be administered by intramuscular injection but the recommended form of administration is a subcutaneous injection via an insulin syringe.
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